Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Our rigorous, data-driven approach to science is supported by strategic business principles that include a broad portfolio of diverse therapeutic modalities, parallel investments, and leveraging global collaborations.

Responsibilities:

* Familiar with display technologies such as phage and/or yeast display.

* Responsible for molecular biology efforts, including cloning and sequence analysis

* Familiar with protein engineering methods such as error prone PCR, saturated mutagenesis, DNA shuffling, etc.

* Supports analysis of protein-protein interactions using appropriate methods (ie, SPR, BLI, ELISA) to achieve engineering and discovery program goals.

* Executes aspects of the antibody discovery process, which may include in vitro screens, sequence analysis, and purification of immune phage-derived sequences.

* Familiarity with tissue culture methods, transfections, and recombinant protein purification.

* With support, evaluates new technologies aimed at expanding Antibody Discovery & Protein Engineering capabilities

* Establishes expertise on critical instrumentation, coordinating support and service to maintain critical operations.

* Performs data analyses and maintains compliance with good record keeping (ELN)

* Supports project, platform and pathway teams by contributing data that achieves team goals.

* Ability to synthesize data and communicate results within Antibody Discovery & Protein Engineering.

Requirements:

* BS with at least 2 years of industry experience, or MS with 0 years industry experience in Biochemistry, Bioengineering, Antibody Engineering, or related field

* Experience with phage display and or yeast display

* Experience with biochemistry techniques including protein quantitation, protein purification, and/or biophysical/biochemical assays

* Expertise with standard text, graphic, and presentation software is required, and familiarity with database/data archival software systems is helpful

* Excellent communication, interpersonal and organizational skills, excited to work in a highly collaborative environment.

Salary Range: $100,000 to $120,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers.

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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