Evercrisp Biosciences, founded by world-renowned scientists who bring expertise and proprietary technology to the company, is currently operating in stealth mode with a substantial Series A commitment from Apple Tree Partners (ATP) to take the company from discovery to proof of concept. Evercrisp is initially focused on high-confidence, genetically validated but "difficult to drug" targets in areas of high unmet need where genome editing can make a significant difference. At Evercrisp, innovation, collaboration, and commitment to making a significant impact on human health guide our work.

The Job
Evercrisp is seeking a curious and mission-driven scientist with domain expertise in Analytical Chemistry, specifically small molecule, oligonucleotide and protein characterization. The ideal candidate will leverage their mass spectrometry and chromatography expertise to develop assays in support of Evercrisp's gene editing platform. With a demonstrated track record in assay development, creative thinking, and cross-functional collaborations, the successful candidate will build key analytical pipelines to support the characterization and development of our gene editing and delivery platforms.

Primary Responsibilities:

• Develop high quality biochemical and analytical assays (LC/UV and LC/MS) to characterize reagents, oligonucleotides and bioconjugates and ensure the highest quality products.
• Coordinate material generation and characterization to support in vitro and in vivo proof of concept studies and meet corporate goals.
• Utilize LC/MS to develop biomarker assays in support of preclinical programs.
• Foster a culture of collaboration, innovation, discovery and cutting-edge research.

Job Requirements:

• M.S. with 6 years or Ph.D. with 2 years of industry experience in nucleic acid chemistry, analytical chemistry, chemical biology, biochemistry or a related field.
• Extensive expertise in the development of analytical assays to support drug product characterization, including LC/UV, LC/MS, CE, and biochemical readouts.
• Successful development of proteomic and metabolic assays is preferred
• Strong working knowledge of Top Down and Bottom Up mass spectrometry-based assays
• Knowledge of purification with different chromatography methods including HPLC, IEX, and SEC for oligonucleotides and protein conjugations.
• Expertise in analytical assessment of oligonucleotides and conjugates thereof preferred
• Experience with gene editing and biochemistry assays is preferred.
• Excellent communication of complex scientific problems with demonstrated creative problem-solving abilities.
• Strong scientific expertise demonstrated by patent and publication track record.
• Ability to present strategies, data and scientific conclusions to a broad audience.
• Ability to set goals with a clear understanding of goal priorities and their impact to research programs, as well as the organization.

Why Evercrisp?

Joining Evercrisp means becoming part of a team dedicated to making a lasting impact on the future of genetic medicine. We offer a dynamic, innovative, and supportive environment where your work will directly contribute to groundbreaking advancements in CRISPR-based technologies.

At Evercrisp, we value diversity, encourage professional growth, and provide competitive benefits and compensation.
Evercrisp is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.