8 Contractor, Biochemist/Biophysicist Jobs in Louisville, CO
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Contractor, Biochemist/Biophysicist
$116k-143k (estimate)
Contractor | Ancillary Healthcare
2 Weeks Ago
Global Pharma Tek is Hiring a Contractor, Biochemist/Biophysicist Near Louisville, CO
Job Title: Biochemist
Location: Louisville, CO 80027
Duration: 12 Months
Shift: 8-5 M-FThis position is an opportunity to learn and grow within a dynamic chemical biology team that supports early molecule discovery. Our multidisciplinary team combines medicinal chemistry, biophysics, structural biology, and enzymology to identify molecular leads that result in targeted oncology therapeutics. We are seeking a Biochemist/Biophysicist that will contribute to the early molecule discovery team, in both bioconjugation as well as biophysical characterization. Responsibilities of this position include producing a variety of customized antibody-drug conjugates, optimizing the conjugation and purification procedures for a variety of biologics and linkers, performing bioanalytical analyses on the resulting conjugates, and biophysically characterizing protein-protein and protein-ligand interactions.
Quals--
Location: Louisville, CO 80027
Duration: 12 Months
Shift: 8-5 M-FThis position is an opportunity to learn and grow within a dynamic chemical biology team that supports early molecule discovery. Our multidisciplinary team combines medicinal chemistry, biophysics, structural biology, and enzymology to identify molecular leads that result in targeted oncology therapeutics. We are seeking a Biochemist/Biophysicist that will contribute to the early molecule discovery team, in both bioconjugation as well as biophysical characterization. Responsibilities of this position include producing a variety of customized antibody-drug conjugates, optimizing the conjugation and purification procedures for a variety of biologics and linkers, performing bioanalytical analyses on the resulting conjugates, and biophysically characterizing protein-protein and protein-ligand interactions.
- Work closely with senior scientists to accomplish team objectives and research milestones.
- Contribute to the development and optimization of conjugation schemes to achieve the required product specifications.
- Commit to producing and maintaining the highest standard of quality in antibody-conjugate productions.
- Perform the following bioconjugation procedures; 1) Antibody and recombinant protein isolation and purification, 2) Purification of antibodies and conjugates using various liquid chromatography methods (IEX, SEC, HIC); 3) Antibody and conjugate validation via various functional tests, 4) Biophysical characterization of proteins and conjugates (e.g., UV/VIS spectrophotometry, DLS, SEC-MALS, native mass-spectrometry Tm or Tagg determination).
- Characterize protein-ligand and protein-protein interactions by a variety of methods including but not limited to; Intact protein and peptide-based mass spectrometry, native mass spectrometry, fluorescence spectroscopy, SPR, BLI, and DSF.
- Biophysically characterize protein samples destined for multiple workflows.
- Learn and develop technical expertise in protein biochemical and biophysical characterization across multiple platforms which may Client outside current skill set.
- Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
- Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team, including maintaining an ELN and uploading data to the database.
- Perform work in compliance with Lilly Research Policies.
Quals--
- BS, MS, or PhD in Biochemistry, Chemical Biology, or related field.
- 2 years hands-on experience in biophysics, bioconjugation, protein labeling, or a combination thereof.
- Direct knowledge in assay development and utilizing SPR/BLI (e.g. Biacore or Octet) or LCMS technologies (e.g. QTOF or Orbitrap)
- Highly organized with excellent analytical, documentation and multi-tasking skills.
- Proven ability to work in a flexible, team-oriented environment.
- Working knowledge of chemical labeling methods and technologies.
- Experience in method or assay development utilizing a variety of LCMS technology (e.g. QTOF or Orbitrap).
- Working knowledge of fluorescent based method or assay development (e.g. FP, FRET, etc).
- Working knowledge in assay development and utilizing SPR/BLI (e.g. Biacore or Octet).
- Excellent interpersonal skills with the ability to communicate and interact well with colleagues at all levels.
- Committed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysical analysis.
Job Summary
JOB TYPE
Contractor
INDUSTRY
Ancillary Healthcare
SALARY
$116k-143k (estimate)
POST DATE
06/06/2024
EXPIRATION DATE
07/01/2024
WEBSITE
globalpharmatek.com
HEADQUARTERS
EDISON, NJ
SIZE
100 - 200
FOUNDED
2011
TYPE
Private
CEO
RAMESH ANUMOLU
REVENUE
$5M - $10M
INDUSTRY
Ancillary Healthcare
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About Global Pharma Tek
Global Pharma Tek provides drug formulation development, clinical trial management, biostatistics and statistical programming services.
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