Hillstar Bio is Hiring a Scientist/Senior Scientist, Protein Analytics Near Boston, MA
About The CompanyHillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston's Seaport neighborhood. Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and other autoimmune diseases. CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). Existing treatment options for CAD have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, and other serious autoimmune conditions with a common biological origin. Job DescriptionJoin Hillstar Bio as a protein analytics leader performing antibody characterization, developability assessment, pre-formulation and DS/DP releasing assays, and working with a skilled team towards achieving our first IND milestone. Establish platforms of antibody characterization, developability assessment, formulation, protein QC and DS/DP specification. Develop and delineate distinctive protein analytics strategies of programs by corroboration with antibody discovery, immunology and CMC groups. This pivotal role offers opportunities to shape our company culture, contribute to organization growth, and make a significant impact on treatment of autoimmune disease to benefit patients. We seek an enthusiastic scientist with extensive hands-on experience, broad knowledge in a variety of advanced biophysical characterization techniques, and strong cross-functional collaborative mindset in a fast-paced environment. Key duties and accountability
This position is for a bench scientist, requiring a commitment of over 60% of your time in the laboratory
Perform reagent QC, biophysical and biochemical protein characterization and antibody developability/manufacturability assessment in all stages of antibody development
Perform formulation and stability study
Manage analytical method development and validation under ICH guideline
Establish DS/DP specifications
Lead development candidate (DC) nomination
Interpret results and communicate within Antibody Research and cross-functional colleagues for successful execution/completion of project
Identify, evaluate, and implement new and existing technologies to improve protein characterization capabilities, throughput, and quality
Maintain detailed laboratory notebooks and write SOPs
Monitor, maintain, and calibrate laboratory instruments and equipment
Proactively share skills and knowledge and train others on techniques and protocols
RequirementsQualifications
MS or PhD in Biochemistry, Biology, or a related field with at least 5 years (MS) or 2 years (PhD) of relevant industrial experience in protein analytics and characterization
Expertise in affinity determination and epitope binning using Octet, ELISA, and SPR
Strong hands-on experience in protein biophysical characterization techniques such as DSF, DSC, SEC-MALS, DLS, Octet, CE, icIEF, HPLC-based assays (SEC, HIC, IEX, etc.)
Experience with ELISA-based specificity screening of mAbs (PSR, DNA, insulin, serum binding assays) is desirable
Experience in CMC management of analytical method validation
Experience with DS/DP GMP stability study and specification
Experience with Flow cytometry is a plus
Master in the efficient execution of highly robust, reproducible, well-documented laboratory experiments and results reporting
Ability to establish and troubleshoot experiments
Excellent organizational and time-management skills with strong attention to detail is a must
Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines
BenefitsCompensation and BenefitsHillstar Bio offers a competitive compensation and benefits package, including a competitive salary, equity, and a comprehensive benefits package. Additional InformationThis is a full-time position located in our Boston, MA office. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.