Our Analytical Development team is growing and we’re seeking a Senior Research Associate to participate in designing and executing experiments, as well as perform sample analysis utilizing HPLC, CE-SDS, iCIEF, and capillary CE-SDS ELISA [simple western blot (Jess)]. These activities will support CMC, discovery, pre-clinical, and clinical development of existing and new lead candidates. This position will directly support the discovery of next-generation immune oncology drugs. It is a hands-on position that requires effective communication and documentation of results to enable the advancement of novel research molecules toward development of clinical candidates, which will ultimately lead to late-stage development and commercialization. Ideal applicants will be agile and highly driven, collaborative, team-oriented, possess excellent communication and organization skills, and carry a strong commitment to excellence.

Essential Functions and Responsibilities:

• Develop and perform HPLC and UPLC assays with minimal supervision including SEC, HIC, IEX, and RP.
• Develop and perform iCIEF and CE-SDS assays.
• Develop and perform ELISAs.
• Perform DLS/SLS analysis using an UNcle instrument and generate datasets that will be used for formulation development studies.
• Perform subvisible particulate matter analysis by HIAC.
• Perform formulation development studies and execute clinical in-use stability studies, transfer formulation knowledge internally.
• Design, conduct, analyze, interpret, and report laboratory experiments; summarize results for meetings and regulatory filings.
• Write and manage SOP’s and test methods, train colleagues and facilitate method transfer to partners and CDMOs.
• Manage and maintain required reagents, laboratory environment, and equipment needed to carry out assignments.
• Draft development reports, method qualification protocols, and method qualification reports
• Prepare presentations for team meetings.
• Work closely with team leaders to complete highest priority work to reach goals and milestones.

Required Skills and Qualifications

• A minimum of a bachelor’s degree and 4-6 years of relevant industry experience or a master’s degree with 3-5 years of relevant industry experience.
• Strong benchtop skills, experience with analysis of protein biologics and peptides.
• Proficient with the development of HPLC and UPLC assays; at least 3 years of experience is required. SEC, RP, HIC, and IEX experience is desired.
• Experience developing and performing ELISAs
• Knowledge and familiarity in employing various analytical techniques, to include but not be limited to: CE-SDS, iCIEF. Experience with DLS/SLS (UNcle), HIAC, HIC and CE-SDS ELISA (Simple Western) blotting or similar technology is desired but not required.
• Experience with formulation development with focus on antibodies or bispecifics is highly desired.
• Ability to perform routine testing and to follow SOPs in a highly accurate and reproducible manner.
• Desire and ability to learn new technologies, thinking outside the box, and exploring new approaches to innovate.
• Training on project specific assays and ability to train others.
• Proven experience with writing and maintaining SOPs, ability to train others and to transfer methods to external partners.
• Ability to work independently; anticipates and solves problems in a proactive fashion.
• Must have excellent computer skills, proficiency with Microsoft Excel and PowerPoint required.
• Good oral and written communication skills a must, excellent team player.

Compensation:

In addition to a competitive base salary ranging from $90,000 to $105,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

Job Type: Full-time

Benefits:

• 401K
• Medical insurance
• Dental insurance
• Vision insurance
• Supplemental disability insurance plans
• Flexible schedule
• Life insurance
• Flexible vacation
• Sick time
• Incentive stock option plan

Schedule:

Monday to Friday

Work authorization:

United States (Required)

Additional Compensation:

Annual targeted bonus %

Work Location:

Onsite; San Diego, CA

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.