Description

Marengo Therapeutics, Inc, a clinical-stage biotech company, develops novel TCR-targeting antibodies that selectively modulate common and disease-specific T cell subsets of the germline TCR repertoire to provide lifelong protection against cancer and other diseases. With a passionate team of dedicated scientists experienced in immunology and oncology, Marengo’s proprietary Selective T Cell Activation Repertoire (STAR) platform leverages an extensive biological understanding of T cell function and receptor signaling to create a world in which everyone’s immune system can defeat cancer. To learn more, visit marengotx.com.

About STAR0602 

STAR0602 is Marengo’s lead program, the first selective T cell activator generated from Marengo’s STAR platform; a library of antibodies targeting non-clonal variable (V)ß regions of the TCR fused to different co-stimulatory moieties. STAR0602 selectively targets a common Vb T cell subset present in all cancers and, by combining a novel non-clonal mode of TCR activation with a T cell co-stimulator in the same molecule, promotes expansion of a new population of clonally enriched, effector memory Vb T cells that turbo-charge immune system and promote a durable anti-tumor immune response. STAR0602 has undergone extensive preclinical testing, which demonstrates potent anti-tumor activity in both mouse and human ex vivo tumor models attributed to a distinct mechanism of action from existing cancer immunotherapies.

The Scientist II role within the “Antibody Technologies & CMC” function is a crucial position at Marengo Therapeutics, Inc. Reporting directly to the Head of our Protein Sciences group, the ideal candidate is a highly motivated, versatile, and experienced scientist in biopharmaceutical process research and analytical sciences. This role is instrumental in supporting both our discovery and development projects. 

As a Scientist II, you will play a pivotal role in our operations. Your responsibilities will include molecular biology, expression, and purification of various protein constructs for numerous projects across Marengo’s pipeline. You will also collaborate with CMC teams, providing valuable input on CMC projects. We expect you to have demonstrated hands-on experience in the production of various biologics, such as Fc-fusions, monoclonal antibodies, and bi and multi-specifics. A strong understanding of cutting-edge expression (Transient and Stable) and purification, as well as basic analytical processes, is also essential.

Who are we looking for?

· You are an energetic and passionate professional who strives to think outside of the box, challenge the norm, and is passionate about the company’s mission of discovering and developing new medications

· You have high attention to detail and a creative approach to problem-solving

· You have a highly analytical mind with exceptional organizational skills

· You are self-motivated with a strong sense of responsibility, integrity, and a collaborative spirit

· You have the ability to work independently to design and troubleshoot experiments while leveraging other team members’ expertise when appropriate

· You are a versatile, quick learner and actively take on new responsibilities 

What are we offering?

· Membership within a growing, CARING, and collegial organization

· Opportunity to become a subject matter expert in certain skills and projects

· Being part of a passionate, involved, and cutting-edge ADPS team

· Exposure to pioneering science and discovering novel therapeutics to help treat patients with cancer

Requirements

Responsibilities:

· Develop methods to establish high-efficiency transient and stable cell production systems to support the production of reagents and therapeutic proteins. 

· Execute hands-on lab work to express, purify, and characterize novel protein therapeutics to support antibody screening and lead optimization in discovery programs

· Protein expression method development using shake flasks, 24 and 96 well plates. Support protein expression scale ranging from 1 mL to 20L.

· Lead process improvements for the lead candidate to support CMC work

· Develop expression and purification workflows to maximize productivity and efficiency

· Act as a Subject Matter Expert in Antibody production and process sciences and provide guidance to the research project teams.

· Analyze and present data, both in written reports and oral presentations.

· Manage collaborations with external CROs.

· Exhibit versatility in taking on new responsibilities within the Antibody Technologies group.

· Act as a champion and represent the Antibody technologies team in project team meetings. Participate in data presentations and cross-functional collaborations, with the opportunity to serve as ADPS lead.

Education and Experience:

· M.S. or PhD in Biochemistry, Molecular Biology, Cell Biology or a closely related field and 5  years experience in Molecular Biology, mammalian cell line development, antibody generation, and bioanalytical characterization is required

· Prior experience in pharma or biotech is required

· Experience in the production of complex Antibody-derived biologics using mammalian host systems and purification using a wide range of AKTA systems

· Strong background and hands-on experience in mammalian cell culture, stable cell line generation and process development

· Expertise and hands-on experience with protein purification methods used in discovery and process development. Expert knowledge of AKTA protein purification systems and chromatography resins

· Experience in characterization of biologics using advanced analytical techniques is a plus

Other professional competencies: 

· Experience working in a matrix environment

· Ability to work independently to design and troubleshoot experiments

· Versatile and quick learner to take on new responsibilities and implement new technologies

Competencies:

Adaptability: Responds resourcefully, flexibly, and positively when faced with new challenges, transitions, and demands. Willingly and effectively deals with the stress and complexities of various situations. Moves forward productively and optimistically under conditions of change and uncertainty.

Collaboration: Embodies and promotes collaboration and works effectively with others across the organization to achieve goals. Demonstrates proficient cross-company communication, cultural sensitivity, and partnership in interactions with others. Involves others in decisions and plans and credits them for their contributions and accomplishments.

Execution: Drives execution of strategic and operating plans while maintaining operational effectiveness. Conveys a strong sense of urgency around continuous improvement, achieving high-quality results, and accelerating business performance. Addresses problems directly and drives 

changes necessary to achieve business objectives.

Relationship Building: Establishes and maintains strong relationships internally and externally. Respects and relates well to management, colleagues, peers, and direct reports. Champions a culture of respect, diversity, and inclusion that values and respects individuals. Earns the respect of others through principled leadership, sound business ethics, and authenticity.

Location: Cambridge, MA ( We are located in Lower Cambridge, called Cambridgeport)

When You Join Marengo, You Will Have:

• Free parking, Cambridge location reachable by public transportation (Red Line)

• Customized and competitive health coverage, including medical offered through BCBS (HMO/PPO), dental, and vision

• Healthcare Saving Account for medical and dependent care expenses

• Eligible from the first day for 401K, no matching

• A robust package of Marengo-paid insurance coverage, including life insurance, short-term and long-term disability

• 20 days of vacation and 1 personal day per year, in addition to 15 company holidays

TO ALL AGENCIES: Please, no phone calls or emails to any employee of Marengo about our openings. All resumes submitted by search firms/employment agencies to any employee at Marengo via email, the internet or in any form and/or method will be deemed the sole property of Marengo unless such search firms/employment agencies were engaged by Marengo for this position and a valid agreement with Marengo is in place. In the event a candidate who was submitted outside of the Marengo agency engagement process is hired, no fee or payment of any kind will be paid.

Marengo Therapeutics, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.