At Neurogene, we focus on bringing life-changing genetic medicines to patients and families affected by rare, devastating neurological diseases. Our clinical-stage company is developing NGN-401 for the treatment of Rett syndrome and NGN-101 for the treatment of CLN5 Batten disease. We are using our proprietary EXACT transgene regulation technology and internal expertise to develop novel approaches and treatments to address the limitations of conventional gene therapy in central nervous system disorders. Our wholly owned and fully operational GMP-capable manufacturing facility supports vector production from research through clinical grade and is designed for commercial-grade production. In addition, Neurogene is now trading on the NASDAQ Global Market. This transformative work is driven by our highly collaborative people and comes together to bring us closer to achieving our mission of turning devastating diseases into treatable conditions, to improve the lives of patients and their families. As an employee of Neurogene, you will be part of building a culture that honors patient and caregiver mindsets and nurtures innovation, creative problem solving and a strong sense of purpose.

Reporting into the Associate Director, the Analytical Scientist will perform and manage analytical testing of AAV batches to support Neurogene’s product development and manufacturing pipeline. The candidate will work across functional groups and with outside testing laboratories to generate high quality results using various protein and cell-based analytical methods. This is a laboratory-based position with the opportunity to supervise an associate. The selected candidate will be a fast learner, have a proven track record of reliable assay performance, collaborate effectively, and have superior organizational skills. Furthermore, the incumbent will be highly independent, have a good work ethic and enjoy working in a growing startup environment.

Accountabilities and Responsibilities

• Lead sample testing efforts using various analytical methods (e.g. ELISA, cell-based assays, flow cytometry and HPLC based assays) to support process development and product characterization activities.
• Perform sample testing, generate reports, and archive and organize assay data.
• Facilitate and participate in the transfer of new methods to the group.
• Collaborate with the process development group and contract analytical testing laboratories effectively to help deliver high quality results in a timely manner.
• Maintain inventory of samples, reagents, and AAV product batches. Manage sample shipments for testing at contract labs.
• Supervise an analyst.

Minimum Requirements

• B.S or M.S. in Biochemistry, Cell Biology, or related field.
• Minimum 2 years in a similar role in a biotech environment or core lab setting required.
• Strong working knowledge of cell and protein-based assays.
• Protein-based methods such as ELISA, enzymatic assays, SDS-PAGE, and Western blotting.
• Routine cell culture and 96-well plate cell-based assays utilizing flow cytometry, immunofluorescence, enzymatic, and other readouts.
• Demonstrated working knowledge of flow cytometry and size exclusion chromatography methods is a plus.
• Demonstrated ability to generate high quality testing data in a reliable and timely manner.
• Great attention to detail with strong documentation and organizational skills.
• Effective interpersonal skills and ability to work both independently and collaboratively in a team structure.

This is a laboratory-based position.