Scientist I/II/Sr. Scientist I, In Vivo Pharmacology

Position Summary:

This position will design and run meaningful in vivo studies to test novel cancer immunotherapies in predictive preclinical animal models. The ideal candidate will have a deep understanding of T cell biology in the context of tumor immunotherapy.

Good things are happening at Omeros!

Come join our Omeros Discovery Team!

Who is Omeros?

Omeros is an innovative biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, immunologic diseases (e.g., complement-mediated diseases) and cancers. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement and is the subject of a biologics license application pending before FDA for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Narsoplimab is also in multiple late-stage clinical development programs focused on other complement-mediated disorders, including IgA nephropathy, atypical hemolytic uremic syndrome, and COVID-19. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is in a Phase 1 clinical trial. For more information about Omeros and its programs, visit www.omeros.com.

Essential Duties & Responsibilities:

• Establish and develop syngeneic and/or humanized mouse models to test our novel therapeutic approaches to immune-oncology
• Design and conduct in vivo and ex vivo pharmacology studies supporting candidate selection and mechanism-of-action studies
• Develop and validate in vivo tumor models, PK/PD methods, and ex vivo immunoprofiling studies, including cell-line derived xenografts, and syngeneic tumor models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics

Education, Experience, Skills, and Knowledge Required:

• A Ph.D. degree in immunology or cancer biology is preferred, with a minimum of 0 - 2 years of related industry experience for a Scientist I, a minimum of 2 years of related industry experience for a Scientist II or a minimum of 4 years of related industry experience for Sr. Scientist I (level will also be determined based on skills and knowledge)
• Hands-on experience designing and running in vivo studies of cell therapies and/or cancer immunotherapies including xenograft and syngeneic and/or humanized mouse tumor (solid and hematologic)
• Strong understanding of T cell biology, tumor immune microenvironment
• Knowledge of the Industrial drug discovery process
• Ability to independently design and execute decision-enabling in vivo studies
• Excellent attention to detail
• Experience managing in vivo electronic databases and records; experienced user of electronic laboratory notebooks

Behavioral Competencies Required:

• Demonstrated ability to build and maintain positive relationships with management, peers, and subordinates
• Demonstrated ability to work in a team-oriented, highly motivated environment including the ability to foster collaboration
• Ability to handle several priorities simultaneously
• Demonstrated commitment to quality
• A passion for professional self-development

Other Requirements:

• Must be willing to work flexible hours to accommodate study requirements/needs

Physical Demands Required:

• Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 20 lbs.
• May encounter prolonged periods of sitting or standing
• This position requires working around hazardous materials

Compensation and Benefits

Omeros is proud to offer a competitive total compensation package designed to support the lives of our employees and their families. The wage scale for the Scientist I (105,000-128,000); Scientist II (120,000-145,000); Sr Scientist (125,000-160,000). Salaries will be determined based on knowledge, skills, education, and experience relevant to the role. Employees are offered medical, dental, vision, life insurance, and a 401(k) plan with a company match. Employees accrue three weeks of vacation and 80 hours of sick time on an annual basis and receive twelve paid holidays throughout the calendar year. This position is eligible for bonus and stock options. To learn more about Omeros, please visit www.omeros.com.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skills, and/or abilities required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to hr@omeros.com or contact Omeros, asking for Human Resources, at (206) 676-5000.