Software Guidance & Assistance, Inc., (SGA), is searching for a Research Associate II/III - Bioanalytical/PKfor a contract assignment with one of our premier Pharmaceutical services clients in South San Francisco, CA.

Responsibilities :

The Preclinical and Translational PKPD (PTPK) Department at the firm is looking for an exceptional laboratory-based contract scientist to work in the investigative PK/ADME group in South San Francisco. This position is to investigate the pharmacokinetics, biodistribution, metabolism, and the PKPD relationships of novel therapeutics in preclinical setting in support of early and late stage drug development. The candidate will be responsible for designing and implementing in-vitro and in-vivo studies that includes cell based in-vitro assay, radiolabeled tissue distribution studies, ADME studies to understand the properties of protein and nucleotide therapeutics. The candidate will interact and develop close partnerships across various functions including Research, Safety Assessment, PD Biomarker, Bioanalytical Assays, Clinical Sciences, Formulation and Regulatory. Additional component of the job will be sample/data analysis and presentation of results to cross-functional teams, department meetings, review committees, internal/external conferences, and regulatory agencies.

• Design and implement in-vitro and in-vivo studies to address ADME questions of protein and nucleotide therapeutic. Writing and submitting protocol to cross functional team for review.
• Carry out sample analysis (including tissue processing) by using different analytical methods.
• Characterize and identify possible biotransformation products from protein and nucleotide therapeutic in different biological matrices.
• Interpret data and communicate results in department meeting and project team meeting.
• Prepare presentation and report for conferences, manuscripts and regulatory documents.

Required Skills:

• A Bachelor's or Master's degree in Biology or Biochemistry with 0-3 years in the Research and Development experience.
• Must have demonstrated a general working knowledge of cell based assay, analytical techniques (HPLC, LSC, mass spectrometry and etc.), and laboratory skills.
• Good oral and written communication skills are important as well as demonstrated effectiveness in working independently and in a team setting.
• Candidate should be highly motivated individual with a passion for science, a curiosity of solving complex problem, attention to detail, as well as demonstrated effectiveness to work independently and in team settings.
• Should also be proficient in a broad variety of lab related technical skills (cell culturing, cell base assay, analytical chemistry, etc.).
• You are expected to have some knowledge in basic pharmacology, drug metabolism (characterizing and identifying metabolite) and in PKPD relationship.
• An individual with strong communication and collaboration skills, along with the ability to clearly articulate solution.

Preferred Skills:

• Understanding of PK concepts and the use of novel drug delivery system is preferred.
• Previous experience in chemistry, especially with working with radio-isotope, is a plus.

SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at https://sgainc.com/ .

SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company EEO page to request an accommodation or assistance regarding our policy.