Company Overview
Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer and Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.
Position Summary
Are you passionate about developing next-generation gene editing therapies? We are seeking highly motivated, talented, and independent in-vivo researchers (Senior Research Associates to Senior Scientists) to grow our diverse, innovation-focused CRISPR-X team that pioneers novel gene editing therapies for human disease. As part of CRISPR Therapeutics, a leading gene editing company, the candidate will be exposed to a broad clinical portfolio. The successful candidate will play an integral role in evaluating and advancing the next generation of genome editing modalities and genetic therapies for a wide range of human indications. The position requires enthusiasm, passion, outstanding in-vivo animal skills, attention to detail, and a desire to create new medicines for patients.
Responsibilities

• Lead, design, and execute research with the aims of exploring and developing next-generation gene editing strategies using CRISPR-based tools and beyond.
• Responsible for in-vivo research and execution across our next-generation modalities, covering hepatic and extra-hepatic target tissues. Lead and conduct hands-on in-vivo research and strategic planning of preclinical projects.
• Opportunities include designing translational in-vivo research strategies to evaluate novel editing modalities, ensuring appropriate resourcing for, and execution of, preclinical in-vivo editing studies as part of the CRISPR-X team, and authoring preclinical content for global regulatory submissions.
• Design, execute, and interpret research requiring in-vivo biology methods including generation, breeding, and maintenance of genetically engineered mouse models; various injection and animal surgery techniques; in-vivo assessment of biomarkers and editing outcomes; longitudinal study of animal health, disease markers, and phenotypic assays; post-mortem preparation of tissue sections, IHC, and other assays.
• Analyze and present experimental data to a wide range of audiences.
• Dissect published literature to find novel solutions to gene editing problems.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
• Oversee the construction and maintenance of technical in-vivo databases, archives and department procedures manuals required for the CRISPR-X function.

Minimum Qualifications

• Extensive prior experience with general animal procedures, familiarity with in-vivo gene editing, including applying and developing next generation gene editing technologies, such as prime editing, base editing, and recombinases and retrotransposons, in an academic and/or industry setting, with a track record demonstrating significant contributions.
• Depending on level, degrees in Biology, Bioengineering, or related disciplines (level commensurate with experience and achievement):
  • Senior Research Associate - 4 to 7 years of relevant research experience, or 2-5 years of experience with advanced degree
  • Principal Research Associate - 6 to 10 years of relevant research experience, or 4-8 years of experience with advanced degree
  • Scientist I - PhD with 0-3 years relevant experience; non-PhD with 8-10 years progressive, relevant experience
  • Scientist II - PhD with 2-5 years relevant experience; non-PhD with 10-12 years progressive, relevant experience
  • Senior Scientist - PhD with 4-8 years relevant experience; non-PhD with 12-15 years progressive, relevant experience
• Deep understanding of rodent (mouse and rat) in-vivo techniques ranging from surgical procedures on neonates to physiological and pathological assessment of diseased adult rodents.
• Excellent technical skills for rodent (mouse and rat) in-vivo work comprising but not limited to IV injections, retro-orbital bleeding, necropsy.
• Experience managing multiple programs and priorities, studies, and external CRO management.
• Strong communicator and activator personality.
• Highly collaborative team player within and across multiple departments.
• Ability to manage and teach while still being hands on.

Preferred Qualifications

• Knowledge and experience in advanced in vivo techniques such as hepatectomies, liver perfusion and hepatocyte isolation, lung function assays and pre-natal treatments.
• Understanding of the evolving regulatory requirements for cell and gene therapy (OTAT) products in the US or ATMP products in Europe.
• Experience with development of Cell and Gene Therapy or ATMP products, and bioassay requirements.

Competencies

• Collaborative - Openness, One Team
• Undaunted - Fearless, Can-do attitude
• Results Orientation - Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit - Proactive. Ownership mindset.

Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
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