At Geneva, we are always on the search for top talent. While this role is not associated with a current opening, one may become available in the near future. Resumes are reviewed on an ongoing basis, and you could be contacted for this role or similar, at anytime. We have a potential need for a Blast Induced Neurotrauma Principal Investigator to support our government customer located in Silver Spring, MD.
Responsibilties

• Leads research and development activities.
• Relies on extensive experience and judgment to plan and accomplish goals.
• May provide consultation on complex projects. A wide degree of creativity and latitude is expected.
• Provide planning preclinical research experiments accounting for the impact of hemorrhagic shock and traumatic brain injury.
• Determine what pathological characteristics are measurable in the acute, subacute, and chronic periods following brain injury.
• Provide scientific and technical support for the research, development, and efficacy evaluation of neuro-protection/neuro-restoration therapies with the ability to fully characterize head injury models defining the temporal profile of histopathology, neurobehavioral (motor/cognitive) dysfunction, molecular (biomarkers/bioenergetics) and electrophysiological (EEG) changes following a "single" or repetitive injury to the brain such as:
• Penetrating Ballistic-like Brain Injury (PBBI) Research
• Projectile Concussive Impact (PCI) Brain Injury Research
• Polytrauma Neurotherapeutic Resuscitation Research using an Aortic Tourniquet
• Neural Stem Cell Research
• TBI Neuroprotection and Neuro-restoration Research
• Non-convulsive Seizures Research
• Molecular Mechanisms, Biomarkers Identification and Therapeutic Intervention for TBI Research
• Conduct and analyze brain trauma neuroprotection, neuro-restoration, and neurotherapeutic research, including therapeutic strategies, blood-brain barrier (BBB) permeability, immune-inflammatory responses, biomarkers, pathology and sequalae following trauma as well as the molecular and cellular mechanisms of brain injury.
• Use models to validate and characterize scaled experimental blast exposure conditions and assess outcomes relevant to blast-injured Warfighters to define the biomechanical and neurobiological underpinnings of blast traumatic brain injury (TBI) and establish effective countermeasures.
• Characterize individual operator blast exposures in a variety of training environments to identify the effects of blast overpressure exposures on cognitive performance, brain and blood biomarkers, and symptom reporting.
• Conduct all aspects of scientific research experiments according to individual reviewed protocols.
• Perform research studies to include writing protocols, executing protocols, analyzing data, and writing manuscripts.
• Communicate and correspond with lead investigator(s) regarding experimental procedures, study progress, concerns about the study, and changes in procedure on a regular and ongoing basis.
• Perform routine and specialized behavior tests and procedures on animals and humans.
• Design and coordinate experiments, provide guidance and assistance to research staff and collaborators, and answer questions about experimental objectives and techniques to be used to fulfill these objectives.
• Recommend equipment acquisitions appropriate for experimental procedures and maintain laboratory inventory of chemical reagents and surgical supplies required for these tasks.
• Compile, analyze, and interpret data.
• Prepare or contribute to the summary of experimental findings for presentation at laboratory discussions, at scientific meetings, in reports, and in scientific journals.
• Assist in the preparing and submitting research proposals to funding agencies along with reports and briefings required for funded research.
• Identify and quantify pathophysiological mediators in biological fluids and tissue extracts as part of an overall effort to recognize biomarkers to non-invasively categorize blast TBI severity and etiology.
• Evaluate neuroprotective pharmacological therapies using neurobehavioral, histopathological, and neurochemical outcome measures.
• Assess the cellular basis for blast-induced brain dysfunction and neuronal injury.
• Routinely review the scientific literature for reports relevant to ongoing research in blast TBI and polytrauma.
• As needed, develop laboratory techniques, and assays; instruct others to correctly use these procedures, and record them as a laboratory Standing Operating Procedure (SOP).

Requirements

• Doctorate degree and post-doctoral training in physiology and/or neuroscience.
• A minimum of 8 years of experience in physiology and/or neuroscience.

• Extensive hands-on experience in rodent surgery and physiological monitoring techniques related to bTBI.
• Demonstrated expertise in a variety of the field's concepts, practices, and procedures.
• Must have the ability to fully characterize head injury models defining the temporal profile of histopathology, neurobehavioral (motor/cognitive) dysfunction, molecular (biomarkers/bioenergetics) and electrophysiological (EEG) changes following a "single" or repetitive injury to the brain such as:
• Penetrating Ballistic-like Brain Injury (PBBI) Research
• Projectile Concussive Impact (PCI) Brain Injury Research
• Polytrauma Neurotherapeutic Resuscitation Research using an Aortic Tourniquet
• Neural Stem Cell Research
• TBI Neuroprotection and Neurorestoration Research
• Non-convulsive Seizures Research
• Molecular Mechanisms, Biomarkers Identification and Therapeutic Intervention for TBI Research

Citizenship And Clearance Requirements

• Must be U.S. Citizen.
• Must hold a minimum DoD Clearance level of Public Trust, with ability to obtain Secret

The Geneva Foundation is an equal opportunity employer and prohibits discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.