Job Description
Wave Life Sciences USA, Inc. seeks Associate Director of Portfolio & Program Mgmt(Bioinformatics) for Lexington, MA offices. Duties inc: Drive, lead, and guide bioinformatics operations, strategic research and project development, and management of therapeutics programs targeting rare and severe neurodegenerative diseases, focused on C9orf72 program team targeting Amyotrophic Lateral, Sclerosis/Fronto-temporal dementia (ALS/FTD) and the Discovery Tox Working Group (DTWG) to: Aid in creation of bioinformatics strategy for current and target drug development programs; Evaluate, establish, and oversee implementation of the Bioinformatics project/program budget and; Evaluate need for new and modified project resources (equipment and staff) and developing plans to attain same. Drive and lead Program Teams with responsibility to: Conduct project scoping for Bioinformatics initiatives, establish project roadmap, and confer with team members on project milestones; Ensure clear and timely communication of Bioinformatics project strategy and progress to leadership and stakeholders and; Work with team members to integrate information from Bioinformatics initiatives into overall project plan. Identify gaps and risks; Oversee team of cross functional scientists supervised by Program Manager including bioinformatics scientists, and additional team members such as biologists, toxicologist in furtherance of drug discovery projects and; Oversee work of staff supervised by Program Manager applying bioinformatics tools and applications in areas including proteomics, transcriptomics, metabolomics, and clinical bioinformatics. Position requires Master's degree, or foreign equivalent in Bioengineering, Biomedical Engineering, or related field, and 7 years' experience in drug discovery and development in industry/academic research environment. Alternatively, will accept Ph.D. , or foreign equivalent in Bioengineering, Biomedical Engineering, or related field, and 4 years' experience in drug discovery and development in industry and/or academic research environment.
Position also requires experience in the following skills, which may be gained concurrently:

• 4 years' experience supporting multiple early-stage drug discovery programs in neurodevelopmental disorders using small molecule and gene therapy approaches.
• 4 years' experience designing and executing experiments in genetic and pharmacological rodent models using in vivo electrophysiological assays such as resting state EEG and auditory evoked potentials.
• 4 years' experience analyzing and interpreting data, and presenting findings to multidisciplinary teams.
• 4 years' experience conducting research on projects involving neurological disorders with responsibility for hands-on experiments in rodent disease models including surgical procedures, awake-behaving electrophysiological recordings, and pharmacological treatments.
• 4 years' experience developing assays and analytical approaches to generate preclinical and translational, disease-relevant endpoints.
• 4 years' experience independently conducting experiments, analyzing and aiding in interpretation of data, and presenting results, conclusions and next steps.
• 2 years' experience performing in vivo electrophysiological recordings in anaesthetized and/or awake-behaving rodents.
• 2 years' experience in local field potential recordings.
• 2 years' experience in analysis of complex data-sets using computer programming including experience with MATLAB.
• 2 years' experience in signal processing methods with FFT.
• 2 years' experience developing and driving discovery and development project goals and plans, leading the identification and development of new bioinformatics software applications, and customizing existing applications to meet specific project needs.
• 1 year experience in development and maintenance of clinical trial master files, including maintenance of documentation related to clinical trial data management and bioinformatics.
• 1 year experience in planning and facilitating the preparation of data, including bioinformatics data for review and assessment by clinical trial safety/data monitoring committees.