Category: Life Science

Employment Type: Direct Hire

Reference: BH-374656

Yoh is hiring a Sr. Staff Scientist/Associate Director - Disease Biology & Translational Sciences for our S. San Francisco, CA client. In this role , will be responsible for helping to establish and expand the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology establishing in vitro/ex vivo models to interrogate complex disease models to rank and screen our therapeutic candidates and establish the drug's mechanism of action for multiple indications. You will lead cell based therapeutic characterization and development efforts defining the compounds mechanism of action and efficacy in complex in vitro models of disease. You will lead from the bench managing internal scientists as well as external CROs to execute strategies and be responsible for the development and conduct of in vitro , and/or ex vivo studies to support and advance company's drug discovery pipeline. You will establish pharmacodynamic and efficacy relationships as appropriate to determine the potential clinical impact of company's drugs. You will serve as the Disease Biology lead on cross-functional research and development teams and have opportunities to lead programs from discovery through early development.
Industry: Drug Discovery
Location: S. San Francisco, CA
Compensation: $175k - $200k (based upon experience)
Type: Direct Hire
Key Responsibilities

• Design and execute in vitro and ex vivo studies to advance therapeutic programs
• Generate, analyze, and interpret complex data to establish functional PK/PD and efficacy relationships and elucidate therapeutic mechanism of action for leads drugs
• Serve as Disease Biology lead on multiple project teams, conduct and trouble-shoot experiments, analyze and interpret data and work cross functionally with colleagues to identify and mitigate risks and effectively advance therapeutic programs
• Help build complex in vitro and ex vivo research and development capabilities
• Author and review protocols, study reports, and regulatory documents to enable IND and other regulatory filings

• PhD Endocrinology, Physiology, Diabetes/Obesity, Immunology / Inflammation, or Metabolic Disease, or related biological science (MSc/BSs with relevant years of experience)
• At least 8 years direct hands-on experience in therapeutic development leveraging indication specific functional disease models in biotechnology and pharmaceutical industries (MSc with at least 12years, BSc with at least 14years)
• MUST have experience with therapeutics programs which have yielded drugs entering clinical development in diabetes or obesity
• Experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g. IF/IHC/ISH), and/or flowcytometry
• Ability to be hands on and working in the lab, manage scientists, write protocols, execute studies leveraging company's in house capabilities or working with CROs
• Direct experimental experience with complex disease biology of diabetes, obesity or other metabolic disease
• Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays
• Leverage complex data sets to characterize therapeutic leads and establish a drug's therapeutic mechanisms of action
• Experience working on/leading project teams with functional responsibility to propose strategy, analyze, interpret, and present complex data to inform decisions
• Ability to collaborate in writing protocols, reports, and regulatory documents
• Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner
• Experience authoring study protocols, reports, and/or regulatory documents including IBs, IND filings, CSRs, and/or NDAs