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Job Title/Position

Scientist I/II, Pharmacology

Location: San Diego

Background

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC).  Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Job Description

As a Scientist specializing in in-vivo preclinical development of novel therapies in radiopharmaceutical treatment, you will guide and execute studies aimed at advancing innovative treatment modalities. In this role, you will design and execute pivotal in-vivo studies aimed at evaluating the efficacy and safety profiles of emerging radiopharmaceutical therapies. Collaborating closely with multidisciplinary teams, you will contribute your expertise in pharmacology and oncology to drive the development and validation of innovative oncology models that mimic disease states and support therapeutic efficacy assessments. This position offers an exciting opportunity to contribute to groundbreaking research aimed at revolutionizing cancer treatment through radiopharmaceutical innovations.

Job Responsibilities

• Work closely with cross-functional teams to develop and implement strategic in vivo study designs that align with project goals and regulatory requirements tailored for radiopharmaceutical therapy (RPT).
• Ensure comprehensive data generation for in vivo pharmacology, supporting decision-making throughout project stages.
• Oversee the acquisition of critical in vivo data essential for advancing RPTs.
• Foster a collaborative environment within the in vivo pharmacology team, sharing resources, expertise and ensure alignment and support for diverse study needs across projects.
• Develop and conduct in vivo studies to assess efficacy, pharmacokinetic/pharmacodynamic relationships, and biomarker identification.
• Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies.
• Collaborate and work with a team of associate scientists engaged in in-vivo pharmacology and translational biology.
• Analyze and present experimental data using Prism, Excel, MS Office or comparable software.
• Innovate in the development of novel in-vivo models, including xenografts, syngeneic tumors, and genetically engineered mouse models relevant to radiopharmaceutical research.
• Ensure adherence to safety and ethical guidelines in research practices.​
• Facilitate the development and execution of relevant in vitro/ex-vivo assays to complement in-vivo studies and enhance scientific insights.

Education and Experience

• BS degree with 8 years, MS with 4-8 years or PhD with 2 years of experience in  Pharmacology, Biology, or related discipline with significant experience in in vivo pharmacology, preferably in oncology research.
• Proven track record of executing in vivo studies in a drug discovery setting.
• Hands on proficiency in rodent handling procedures and in vivo skills including dosing (IV, IP, SC, PO), blood collection, tumor implantation, necropsy, etc.
• Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable. 

Skills

• Expertise in designing and conducting in vivo experiments, including proficiency in tumor models and therapeutic interventions.
• Strong analytical and problem-solving skills, with the ability to interpret complex data sets and draw meaningful conclusions.
• Excellent communication skills, both verbal and written, with the ability to effectively collaborate within cross-functional teams and work in a fast-paced, dynamic, and collaborative environment.
• Ability to thrive in a dynamic and fast-paced research environment, managing multiple projects simultaneously.
• Commitment to scientific excellence, integrity, and continuous learning.
• Ability to work with radioisotopes with strict adherence to radiation safety protocols.

The starting compensation for this job is a range from $109,000 - 150,700, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.  

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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