What are the responsibilities and job description for the Scientist - Oligonucleotide Analytics position at Integrated Resources, Inc ( IRI )?
Responsibilities:
- Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
- Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
- Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
- Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
- Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
- Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
- Support integrity confirmation requests (such as concentration) by assay development and biology teams
- Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
- Ensure the supply of laboratory consumables and reagents are in stock as needed
- Maintain a high level of productivity in the laboratory setting.
- Present data and reports on project status at individual, group, and departmental meetings.
Qualifications:
- Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
- Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Salary : $52
