What are the responsibilities and job description for the Scientist I, Oligonucleotide Analytics position at Net2Source Inc.?
Job Title: Scientist I, Oligonucleotide Analytics
Location: San Diego, CA 92121
100% Onsite
Duration: 06 months contract
Notes from HM:
- Role is Oligonucleotide Analytics and/or Analytical Chemistry
- PhD degree required in a related field
- Performing quality control routines
- Characterizing molecules
- Must have at least 1 year of industry experience with PhD
Top Skills needed:
- Oligonucleotide analytics
- Analytical chemistry
- siRNA experience a MUST
- LCMS experience
Key Responsibilities:
30% • Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% • Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% • Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% • Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% • Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
• Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
• Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% • Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% • Ensure the supply of laboratory consumables and reagents are in stock as needed
• Maintain a high level of productivity in the laboratory setting.
2% • Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
• Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
• Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Salary : $48 - $52
