What are the responsibilities and job description for the Senior Director, Clinical Sciences position at Maze Therapeutics?
The Position
Maze Therapeutics is seeking a Senior Director, Clinical Sciences to play a pivotal role in translating groundbreaking genetic discoveries into life-changing treatments. As a key member of our Clinical Sciences team, you will drive the clinical development of innovative therapies, including our small molecule targeting APOL1, a major genetic contributor to chronic kidney disease.
Beyond APOL1, Maze is advancing a pipeline of precision medicines for renal, cardiac, and metabolic diseases, including promising treatments for chronic kidney disease and phenylketonuria. Your leadership will help shape these programs, turning scientific insights into tangible clinical advancements that have the potential to transform lives.
This role requires a strategic and hands-on leader who thrives in a fast-paced, collaborative environment. You will partner with cross-functional teams to design, execute, and interpret clinical studies, ensuring our programs are built on scientific rigor and patient impact.
The Impact You’ll Have
- Lead clinical trial strategy and execution for the APOL1 program and additional early-stage clinical assets
- Design and oversee key clinical trials, including first-in-human and proof-of-concept studies, in partnership with cross-functional teams.
- Author clinical-regulatory documents , such as protocols, amendments, informed consent forms, study reports, and statistical analysis plans (SAPs).
- Engage with key stakeholders , including investigators, scientific thought leaders, and patient advocacy groups to gather insights, refine strategies and build awareness and enthusiasm for Maze’s pipeline.
- Partner with Clinical Development Operations to identify, select, and build strong relationships with investigators, study sites, and CROs
- Develop and integrate timelines and budgets for company-wide objectives by working closely with project management, CMC, nonclinical development, and regulatory affairs.
- Represent Maze at industry conferences, regulatory meetings, and advisory boards , helping to elevate the company’s scientific and clinical presence.
As a Senior Director, we also expect our leaders to demonstrate the following Leadership Competencies :
Role models clear communication and open two-way conversations.
Champions collaboration and connection across Maze.
Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success.
Develops staff capabilities to handle delegation of responsibilities.
What We’re Looking For
About Maze Therapeutics
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $290,000 - $354,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
Salary : $290,000 - $354,000
