What are the responsibilities and job description for the Senior Director, Clinical Sciences position at Mazetx?
The Position
Maze Therapeutics is seeking a
Senior Director, Clinical Sciences
to play a pivotal role in translating groundbreaking genetic discoveries into life-changing treatments. As a key member of our Clinical Sciences team, you will drive the clinical development of innovative therapies, including our small molecule targeting APOL1, a major genetic contributor to chronic kidney disease.Beyond APOL1, Maze is advancing a pipeline of precision medicines for renal, cardiac, and metabolic diseases, including promising treatments for chronic kidney disease and phenylketonuria. Your leadership will help shape these programs, turning scientific insights into tangible clinical advancements that have the potential to transform lives.This role requires a strategic and hands-on leader who thrives in a fast-paced, collaborative environment. You will partner with cross-functional teams to design, execute, and interpret clinical studies, ensuring our programs are built on scientific rigor and patient impact.
The Impact You’ll Have
Lead clinical trial strategy and execution
for the APOL1 program and additional early-stage clinical assets
Design and oversee key clinical
trials, including first-in-human and proof-of-concept studies, in partnership with cross-functional teams.
Author clinical-regulatory documents
such as protocols, amendments, informed consent forms, study reports, and statistical analysis plans (SAPs).
Engage with key stakeholders
including investigators,scientific thought leaders, and patient advocacy groups to gather insights, refine strategies and build awareness and enthusiasm for Maze’s pipeline.
Partner with Clinical Development Operations
to identify, select, and build strong relationships with investigators, study sites, and CROs
Develop and integrate
timelines and budgets
for company-wide objectives by working closely with project management, CMC, nonclinical development, and regulatory affairs.
Represent Maze at industry conferences, regulatory meetings, and advisory boards
helping to elevate the company’s scientific and clinical presence.As a Senior Director, we also expect our leaders to demonstrate the following Leadership Competencies :
Communication and Influence
Role models clear communication and open two-way conversations. Reinforces an environment where people feel heard and their opinions are valued. Inspires followership despite differing initial opinions.
Teamwork and Collaboration
Champions collaboration and connection across Maze. Establishes team norms and expectations. Seeks opportunities to spotlight team and individual contributions in public forums.
Execution and Results
Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success. Coaches others on resource management and work distribution / delegation. Aligns work to Maze’s strategy mission and vision.
Develop Others and Self
Develops staff capabilities to handle delegation of responsibilities. Encourages staff to develop and execute personal stretch goals. Identifies and recommends ways to increase inclusive leadership.
What We’re Looking For
PhD / MD / PharmD with 5 years of drug development industry experience. Prior drug development experience in nephrology or cardiometabolic diseases is preferred but not required.
Demonstrated knowledge and experience in the clinical trial design, conduct , and data interpretation, particularly for Phase 2 trials.
Strong leadership experience to drive cross-functional study team and align clinical strategies with corporate objectives.
Ability to foster relationships with investigators, site study staff, patient advocacy groups, and external partners to support the clinical programs.
Exceptional organizational, analytical, and communication skills, ensuring high-quality execution of clinical programs
A positive and adaptable mindset with high ethical standards and a passion for advancing groundbreaking therapies.
Willingness to travel up to 20% domestically and internationally for regulatory discussions, vendor visits, and industry conferences.
About Maze Therapeutics
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together
Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed
We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True
Our integrity is foundational; it guides us no matter the obstacle. The expected annual salary range for employees located in the San Francisco Bay Area is $290,000 - $354,000. Additionally, this position is eligible for an annual performance bonus.Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.EducationSelect... Select... Select... If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows : A "disabled veteran" is one of the following : a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.An "active duty wartime or campaign badge veteran" means a veteran#J-18808-Ljbffr
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San Francisco, CA
Full Time